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Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines

โœ Scribed by Makoto Naoi; Tsutomu Takahashi; Hiroshi Ichinose; Keiji Wakabayashi; Takashi Sugimura; Toshiharu Nagatsu


Book ID
117057867
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
308 KB
Volume
157
Category
Article
ISSN
0006-291X

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Aromatic l-amino acid decarboxylase (AADC) and tyrosine hydroxylase (TH) are involved in the synthesis of dopamine and other monoamine neurotransmitters, and their activities can be regulated by a number of physiological stimuli. An interesting finding has been that (2)-deprenyl and some other irrev