## Abstract We showed that lipopolysaccharide (LPS) or hypoxia and reoxygenation (H/R) decreases electrical coupling between microvascular endothelial cells by targeting the gap junction protein connexin40 (Cx40), tyrosine kinaseβ, ERK1/2β, and PKAβdependently. Since LPS can compromise microvascula
β¦ LIBER β¦
Reduction of electrical coupling between microvascular endothelial cells by NO depends on connexin37
β Scribed by McKinnon, R. L.; Bolon, M. L.; Wang, H.-X.; Swarbreck, S.; Kidder, G. M.; Simon, A. M.; Tyml, K.
- Book ID
- 111925704
- Publisher
- The American Physiological Society
- Year
- 2009
- Tongue
- English
- Weight
- 876 KB
- Volume
- 297
- Category
- Article
- ISSN
- 0363-6135
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## Abstract Electrical coupling along the endothelium is central in the arteriolar conducted response and in control of vascular resistance. It has been shown that exposure of endothelium to lipopolysaccharide (LPS, an initiating factor in sepsis) reduces intercellular communication in vitro and in