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Reduction of CD3-mediated apoptosis in human T cells by CD28-costimulation: Possible mechanisms

✍ Scribed by Y. Müller; E. Wierenga; R. Mailhammer; W. Wilmanns; G. Jung

Book ID
117665646
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
122 KB
Volume
33
Category
Article
ISSN
0959-8049

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## Abstract The T cell surface protein CD28 provides a critical costimulatory signal for T cell activation. With age, humans accumulate increasing numbers of CD28^–^ T cells, and this loss of CD28 expression is exacerbated certain disease states, such as HIV infection, autoimmune conditions or canc