Reduction of Camphthotecine by 1,4-dihydropyridine
✍ Scribed by A. N. Ivchenko; A. N. Balaev; E. A. Ruchko; V. E. Fedorov
- Book ID
- 121854110
- Publisher
- Springer US
- Year
- 2014
- Tongue
- English
- Weight
- 115 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0009-3122
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## Abstract Zinc(II) promotes the reduction of unactivated ketones and aldehydes by (methyl‐substituted) 1‐methyl‐1,4‐dihydropyridines. Coordination of the dihydropyridines to the metal, which occurs via their annular nitrogen atoms, is essential for hydrogen‐transfer. The reductions proceed best i
## Abstract The Mg(ClO~4~)~2~‐induced reduction of racemic benzoin by the racemic NADH model compound 3‐(dimethylcarbamoyl)‐1,2,4‐trimethyl‐1,4‐dihydropyridine (1), in accordance to Cram's rule, leads exclusively to __meso__‐1,2‐diphenyl‐1,2‐ethanediol. However, while __R__‐1 equally reduces 5‐benz