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Reduction of Active Elastase Concentration by Means of Immobilized Inhibitors: A Novel Therapeutic Approach

โœ Scribed by Valentina Grano; Gianluca Tasco; Rita Casadio; Nadia Diano; Marianna Portaccio; Sergio Rossi; Umberto Bencivenga; Mario Compiani; Anna de Maio; Damiano Gustavo Mita


Book ID
109386943
Publisher
American Institute of Chemical Engineers
Year
2004
Tongue
English
Weight
444 KB
Volume
20
Category
Article
ISSN
8756-7938

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โœ T. Fujita ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 475 KB

A 27-picosecond (ps) molecular dynamics calculation has been carried out for the 1:2 enzyme-ligand complex between porcine pancreatic elastase (PPE) and acetyl-alanine-proline-alanine (APA). A data analysis has been carried out using a total of 450 structures. During the simulation, the root-mean-sq