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Reduction of 1-(5-uracilylmethyl)pyridinium salts by thiols to thymine derivatives. A model of the thymidylate synthase reaction

✍ Scribed by Erwin Vega; Eduard R. de Waard; Upendra K. Pandit

Book ID
104589152
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
159 KB
Volume
109
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

1‐(5‐uracilylmethyl)pyridinium salts react with 9, 10‐dihydrophenanthridine, Hantzsch ester or thiols (RSH, R = p‐nitrobenzyl, t‐butyl) to form thymine derivatives. The mechanisms of the reactions are discussed.

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