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Reduction in ischemic myocardial K+ efflux and arrhythmias by glibenclamide

โœ Scribed by PF Kantor; WA Coetzee; SC Dennis; LH Opie

Book ID
118916622
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
112 KB
Volume
20
Category
Article
ISSN
0022-2828

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ATP-sensitive K-channels in HIT T15ฮฒ-cel
ATP-sensitive K-channels in HIT T15ฮฒ-cells studied by patch-clamp methods,86Rb efflux and glibenclamide binding
โœ I. Niki; R. P. Kelly; S. J. H. Ashcroft; Frances M. Ashcroft ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 1020 KB

ATP-sensitive K-channels in the cloned beta-cell line HIT T15 were studied by patch-clamp methods; by measurement of 86Rb efflux; and by [3H]glibenclamide binding to isolated membrane preparations. In inside-out patches a 50 pS K-channel was found which was blocked by ATP or tolbutamide applied to t