Reduction in hMSH2 mRNA Levels by Premature Translation Termination (Implications for Mutation Screening in Hereditary Nonpolyposis Colorectal Cancer)

Germ line mutations of hMSH2 and hMLH1 g

Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients

✍ M. Miyaki; M. Konishi; M. Muraoka; R. Kikuchi-Yanoshita; K. Tanaka; T. Iwama; T. 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 848 KB

Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o