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Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

✍ Scribed by Brigitte Potier; Jean-Marie Billard; Sylvain Rivière; Pierre-Marie Sinet; Isabelle Denis; Gaelle Champeil-Potokar; Barbara Grintal; Anne Jouvenceau; Melanie Kollen; Patrick Dutar


Book ID
111199653
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
716 KB
Volume
9
Category
Article
ISSN
1474-9718

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The effects of aging on activation of metabotropic glutamate (mGlu) receptors were studied in the CA1 field of hippocampal slices from young (3-to 4-month-old) and aged (24-to 27-month-old) Sprague-Dawley rats with the use of ex vivo electrophysiological recording techniques. The depolarization of m