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Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing

✍ Scribed by Qian, Hong; Xu, Xiangru


Book ID
121673976
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
162 KB
Volume
23
Category
Article
ISSN
0906-6705

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## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^‐methylguanine‐DNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu