Reduction in cell surface Concanavalin A binding and mannose incorporation into glycoproteins of Sarcoma 180 by 6-thioguanine

Inhibition of mannose incorporation into

Inhibition of mannose incorporation into glycoproteins and dolichol-linked intermediates of sarcoma 180 cells by 6-methylmercaptopurine ribonucleoside

✍ John A. Sokoloski; Alan C. Sartorelli 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 676 KB

6-Methylmercaptopurine ribonucleoside (CMMPR), an inhibitor of purine nucleotide biosynthesis de novo, was used as a model compound t o evaluate the relationship between the levels of intracellular guanosine triphosphate (GTP) and the formation of cellular glycoproteins and their dolichol-oligosacch