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Reduction by interferon-α of levels of c-myc protein and DNA synthesis in a human hepatoma cell line mediated by inhibition of putrescine synthesis

✍ Scribed by Tadashi Takeda; Shuhei Nishiguchi; Tetsuo Kuroki; Kenzo Kobayashi; Tadayoshi Hasuma; Isao Matsui-Yuasa; Shuzo Otani


Book ID
115764580
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
651 KB
Volume
178
Category
Article
ISSN
0006-291X

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✍ Nils-Erik Heldin; Ylva Paulsson; Karin Forsberg; Carl-Henrik Heldin; Bengt Weste 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 785 KB

We have studied the effect of increased intracellular levels of cyclic AMP on the growth response to platelet-derived growth factor (PDGF) of human foreskin fibroblasts in culture. It was found that forskolin, a potent stimulator of adenylate cyclase activity, inhibits the stimulatory effect of PDGF