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Reducing effects of rodent malaria on hepatic carcinogenesis induced by dietary aflatoxin B1

✍ Scribed by Subhkij Angsubhakorn; Natth Bhamarapravati; Somphong Sahaphong; Permsin Sathiropas

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 591 KB
Volume: 41
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910410114

No coin nor oath required. For personal study only.

✦ Synopsis

The present study was undertaken to evaluate the effects of Plasmodium berghei infection on the development of liver tumors induced in male Buffalo rats by aflatoxin 8, (AFB,). Intraperitoneal (i.p.) injection of lo6 parasitized red blood cells (pRBC) into the rat I2 days prior to administration of 2 ppm dietary AFB, for 10 weeks diminished hepatocellular carcinoma (HCC) induction compared to that observed in rats given AFB, alone at weeks 60-82. No animals in a control group developed HCC lesions, while only I of 22 rats treated with P. berghei alone developed a neoplastic nodule at week 82. These data suggest a reducing effect of P. berghei on the development of liver tumors induced by AFB, in male Buffalo rats.

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