Reduced von Willebrand factor secretion is associated with loss of Weibel–Palade body formation

Osteoprotegerin (OPG) is localized to th

Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor

✍ A.C.W. Zannettino; C.A. Holding; P. Diamond; G.J. Atkins; P. Kostakis; A. Farrug 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

## Abstract Recent studies demonstrate roles for osteoprotegerin (OPG) in both skeletal and extra‐skeletal tissues. Although its role in preventing osteoclast (OC) formation and activity is well documented, emerging evidence suggests a role of OPG in endothelial cell survival and the prevention of