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Reduced Urinary Excretion of Thiazide-Sensitive Na-Cl Cotransporter in Gitelman Syndrome: Preliminary Data

✍ Scribed by Kwon Wook Joo; Jay Wook Lee; Hye Ryoun Jang; Nam Ju Heo; Un Sil Jeon; Yun Kyu Oh; Chun Soo Lim; Ki Young Na; Jin Kim; Hae Il Cheong; Jin Suk Han


Book ID
114468126
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
866 KB
Volume
50
Category
Article
ISSN
0272-6386

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Generation and analysis of the thiazide-
✍ Sung-Sen Yang; Yi-Fen Lo; I-Shing Yu; Shu-Wha Lin; Tai-Hsiang Chang; Yu-Juei Hsu πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 660 KB

Gitelman syndrome (GS) is characterized by salt-losing hypotension, hypomagnesemia, hypokalemic metabolic alkalosis, and hypocalciuria. To better model human GS caused by a specific mutation in the thiazidesensitive Na 1 -Cl Γ€ cotransporter (NCC) gene SLC12A3, we generated a nonsense Ncc Ser707X kno