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Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis

✍ Scribed by Tabrizi, M; Yang, W; Jiao, H; DeVries, E M G; Platanias, L C; Arico, M; Yi, T


Book ID
110053778
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
138 KB
Volume
12
Category
Article
ISSN
0887-6924

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Reduced Tyk2/SHP-1 interaction and lack
✍ Tabrizi, M; Yang, W; Jiao, H; DeVries, E M G; Platanias, L C; Arico, M; Yi, T πŸ“‚ Article πŸ“… 1998 πŸ› Nature Publishing Group 🌐 English βš– 138 KB

Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disease with features similar to those of the murine motheaten phenotype resulting from mutations of protein tyrosine phosphatase SHP-1. This has raised the possibility that defects in SHP-1 or SHP-1-regulated signaling mol