Reduced Tyk2/SHP-1 interaction and lack
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Tabrizi, M; Yang, W; Jiao, H; DeVries, E M G; Platanias, L C; Arico, M; Yi, T
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Article
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1998
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Nature Publishing Group
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English
β 138 KB
Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disease with features similar to those of the murine motheaten phenotype resulting from mutations of protein tyrosine phosphatase SHP-1. This has raised the possibility that defects in SHP-1 or SHP-1-regulated signaling mol