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Reduced transplantability of syngeneic tumors in rats immunized with allogeneic tumors

✍ Scribed by Hiroshi Kobayashi; Eiki Gotohda; Noboru Kuzumaki; Noritoshi Takeichi; Masuo Hosokawa; Tadao Kodama

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
538 KB
Volume
13
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The growth of transplanted syngeneic tumors in Wistar/KA (WKA) rats was inhibited by three immunizations with tumors from allogeneic Donryu rats which possibly are unrelated antigenically. Inhibition of syngeneic tumor growth was not associated with the source or type of the tumors (carcinoma and sarcoma) used. A slight inhibition was also observed in rats immunized with a large amount of xenogeneic tumor or allogeneic normal spleen, liver and kidney cells. Inhibition was also observed after immunization with syngeneic tumors artificially infected with murine leukemia virus. However, the inhibition was strongest in rats immunized with allogeneic tumors. The mechanism of inhibition may be immunological, and it may be associated with an increase in the non‐specific immunity of the host.

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