Reduced threshold for cortical spreading depression in female mice
✍ Scribed by Kevin C. Brennan; Marcela Romero-Reyes; Héctor E. López Valdés; Arthur P. Arnold; Andrew C. Charles
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 175 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle. Ann Neurol 2007