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Reduced synthesis of hepatic microsomal cytochrome P450 in the bile duct ligated rat

✍ Scribed by A.M. Mackinnon; F.R. Simon


Book ID
118309615
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
486 KB
Volume
56
Category
Article
ISSN
0006-291X

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The effects of bile duct ligation (BDL) on the activity and content of individual hepatic mixed-function oxi- dases (IMFOs) was examined. Five days after BDL, hepatic microsomal total cytochrome P450 (CYP) content and NADPH-cytochrome P450-reductase (P450-reductase) activity were reduced to 56% and