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Reduced spinal reflexes following intrathecal baclofen in the rabbit

✍ Scribed by J. S. Kroin; R. D. Penn; R. L. Beissinger; R. C. Arzbaecher

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
389 KB
Volume
54
Category
Article
ISSN
0014-4819

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✦ Synopsis

Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5-5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 micrograms or less, the forelimbs were unaffected.

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