Reduced short-term obsessive–compulsive symptoms in schizophrenic patients treated with risperidone: a single-blind prospective study
✍ Scribed by Baybars Veznedaroglu; Eyup Sabri Ercan; Bulent Kayahan; Azmi Varan; Erhan Bayraktar
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 79 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0885-6222
- DOI
- 10.1002/hup.536
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✦ Synopsis
Abstract
Background
Risperidone is a widely used agent as first‐line treatment in schizophrenia with a favorable side‐effect profile. However, a number of case reports have suggested an increase in obsessive–compulsive symptoms in patients treated with risperidone.
Objective
The aim of this study was to investigate the effect of risperidone on obsessive–compulsive symptoms in the treatment of schizophrenia.
Method
Forty patients with DSM‐IV diagnosis of schizophrenia were included in the study. The Yale‐Brown obsessive compulsive scale was administered before, at the end of first and second months of treatment. Paired‐samples t‐test was used to compare the three assessments.
Results
There was not an increase, but a significant decrease, in YBOCS scores over time during risperidone treatment (p<0.05).
Conclusion
In the present study risperidone caused a significant decrease in obsessive–compulsive symptoms in the treatment of schizophrenia. Copyright © 2003 John Wiley & Sons, Ltd.