𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reduced response of scleroderma fibroblasts to fibroblast growth factor

✍ Scribed by K. Nishioka; Y. Kobayashi; I. Katayama; S. Sano

Book ID
104764684
Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
412 KB
Volume
276
Category
Article
ISSN
0340-3696

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✦ Synopsis

Reactivity of scleroderma fibroblasts to lymphoid cell-derived fibroblast growth factor (FGF) was assessed in this study. The fibroblasts from the sclerotic lesion failed to respond to FGF, whereas those from scleroedematous lesions responded equally to normal fibroblast. Response of the fibroblast from sclerotic lesion was also lower than that of the fibroblast from mature scar. Fibroblasts obtained from three different layers of healthy skin, papillary dermis, reticular dermis, and reticular-subcutaneous layer, responded equally to FGF, whereas the fibroblast of reticular dermis from sclerotic lesion failed to respond to FGF. It is suggested that the fibroblast of reticular dermis in scleroderma is variously activated by some unknown factors, so that they do not have enough reserve to respond to further stimuli.

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Response of scleroderma fibroblasts to v
Response of scleroderma fibroblasts to various growth factors
✍ K. Takehara; Y. Soma; A. Igarashi; K. Kikuchi; A. Moro; Y. Ishibashi πŸ“‚ Article πŸ“… 1991 πŸ› Springer-Verlag 🌐 English βš– 434 KB

Abnormal growth regulation in lesional skin fibroblasts may be related to scleroderma pathogenesis. We report on the abnormal response of cultured fibroblasts derived from sclerotic lesions to various growth factors. We investigated the responses of skin fibroblasts (10 strains) and normal fibroblas