## Abstract Chromatin remodeling of the bone‐specific rat osteocalcin (OC) gene accompanies the onset and increase in OC expression during osteoblast differentiation. In osseous cells expressing OC, the promoter region contains two nuclease hypersensitive sites that encompass the elements that regu
Reduced Proliferation and Osteocalcin Expression in Osteoblasts of Male Idiopathic Osteoporosis
✍ Scribed by Sílvia Ruiz-Gaspà; Josep Blanch-Rubió; Manuel Ciria-Recasens; Jordi Monfort; Laura Tío; Natàlia Garcia-Giralt; Xavier Nogués; Joan C. Monllau; Jordi Carbonell-Abelló; Lluis Pérez-Edo
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 267 KB
- Volume
- 86
- Category
- Article
- ISSN
- 1432-0827
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In western countries, osteoporosis affects at least 1 in 12 of all adult males and a third of osteoporotic men have idiopathic disease (MIO). Both oestrogen and testosterone are now known to be important to the male skeleton. As normal oestrogen levels have been found in younger MIO cases, it is hyp
## Abstract To clarify the mechanism of the stimulatory effect of statins on bone formation, we have assessed the effect of simvastatin and atorvastatin on osteoblast activity by analysing cell proliferation, as well as collagen, osteocalcin, and bone morphogenetic protein‐2 (__BMP2__) gene express
## Abstract Livers from wild‐type and p53‐deficient mice were analyzed for the expression of cell‐cycle regulatory proteins in an attempt to determine the mechanism for the increased proliferation of liver cells in p53‐deficient mice associated with enhanced susceptibility to aflatoxin‐induced live
## Abstract Male idiopathic osteoporosis (MIO) is a metabolic bone disease that is characterized by low bone mass, microstructural alterations, and increased fracture risk in otherwise healthy men. Although the detailed pathophysiology of MIO has yet to be clarified, evidence increasingly suggests