Reduced production of lactate during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats
β Scribed by Kazuo Yamagata; Motoki Tagami; Katsumi Ikeda; Takanori Noguchi; Yukio Yamori; Yasuo Nara
- Book ID
- 117471277
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 97 KB
- Volume
- 296
- Category
- Article
- ISSN
- 0304-3940
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## Abstract Nitric oxide (NO) leads to neuronal death in ischemia/reperfusion (I/R), including stroke. Here, we examined the NOβinduced vulnerability of neurons and lactate production by astrocytes in strokeβprone spontaneously hypertensive rats (SHRSP) __in vitro__. Neuronal cell death induced by
Glial cell line-derived neurotrophic factor (GDNF) plays several important roles in the survival and recovery of mature neurons during ischemia. We examined the possibility that the expression of GDNF mRNA and the release of GDNF protein are regulated differentially in cultured astrocytes from the s