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Reduced numbers of regulatory T cells in breast carcinoma with medullary features

✍ Scribed by Joaquim S Vong; Alex M C Yu; David C H Ng; Philip C W Lui; Bonita K B Law; Helen H L Chau; Puay-Hoon Tan; Gary M Tse

Book ID: 110092826
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 589 KB
Volume: 59
Category: Article
ISSN: 0309-0167
DOI: 10.1111/j.1365-2559.2011.03903.x

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## Abstract Tyrosine kinase inhibitors (TKIs) as sorafenib are known to reduce the number of immunosuppressive regulatory T cells (Tregs) in the peripheral blood and thereby shifting the immune balance to a more stimulating setting. The effect of sorafenib on intratumoural Tregs is unclear but impo