Reduced NO synthesis and eNOS mRNA expression in endothelial cells from newborns with a strong family history of type 2 diabetes

HUVECs from newborns with a strong famil

HUVECs from newborns with a strong family history of diabetes show diminished ROS synthesis in the presence of high glucose concentrations

✍ Noé Alvarado-Vásquez; Araceli Páez; Estrella Zapata; Susana Alcázar-Leyva; Edgar 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 351 KB

## Abstract ## Background A family history of type 2 diabetes mellitus (DM) increases the probability to develop DM and endothelial dysfunction. The probable mechanism involves augmented reactive oxygen species (ROS) synthesis. The aim of this study was to evaluate the synthesis of ROS in human um