Reduced neutrophil superoxide generation and plasma lipoperoxide levels in pigs fed with cod liver oil
✍ Scribed by Dr. Carlo Guarnieri; Li You-Zhou; Elizabeth Roth; Pierluigi Biagi; Giovanni Ussia; Elisabetta Baccarini; Francesco Farruggia; Gary L. Anderson; John H. Barker; Giovanni Galletti
- Book ID
- 101822292
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 483 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0263-6484
No coin nor oath required. For personal study only.
✦ Synopsis
Circulating neutrophils, isolated from pigs fed for 8 weeks with a diet supplemented with CLO, had an accentuated n-3 fatty acid incorporation into the plasma membrane, as evidenced by an approximately four-fold greater n-3;n-6 ratio as compared with the control diet group. Moreover, the neutrophils of the CLO fed pigs produced less superoxide when stimulated with PMA or f-MLP, as well as showing a more prolonged latency period before 0, -generation. In the plasma of pigs fed with CLO there were higher levels of thiobarbituric reactive material and lipofuscin. while the content of GSSG was similar in both dietary groups.
The results of this study indicate that dietary supplementation with CLO reduces the activation of circulating neutrophils and favours the presence in the plasma of lipoperoxides.