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Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle

✍ Scribed by David J. Marcinek; Kenneth A. Schenkman; Wayne A. Ciesielski; Donghoon Lee; Kevin E. Conley

Book ID: 110113672
Publisher: Cambridge University Press
Year: 2005
Tongue: English
Weight: 161 KB
Volume: 569
Category: Article
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2005.097782

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The abundance of mitochondrial DNA (mtDNA) deletions has been shown to increase with age in a number of species and may contribute to the aging process. Estimating the total mtDNA deletion load of an individual is essential in evaluating the potential physiological impact. In this study, we compared