Reduced membrane protein associated with resistance of human squamous carcinoma cells to methotrexate and cis-platinum
β Scribed by Samuel D. Bernal; Jonathan A. Speak; Klaus Boeheim; Arnon I. Dreyfuss; Joel E. Wright; Beverly A. Teicher; Andre Rosowsky; Sai-Wah Tsao; Yuk-Chor Wong
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 769 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0300-8177
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract About 45% of head and neck squamous cell carcinomas (HNSCC) are characterized by amplification of chromosomal band 11q13. This amplification occurs by a breakageβfusionβbridge (BFB) cycle mechanism. The first step in the BFB cycle involves breakage and loss of distal 11q, from __FRA11F_
## Abstract It has been previously demonstrated that human carcinomas express interleukinβ2 receptor (ILβ2R) Ξ±, Ξ², and Ξ³ chains. The Ξ² and Ξ³ chains of ILβ2R have intermediate binding affinity for ILβ2 and are responsible for the intracellular signaling cascades after ILβ2 stimulation. ILβ2RΞ± lacks
Forty-one patients with unresectable Stage IV head and neck squamous cell carcinoma were treated with combined modality therapy (CM) consisting of induction chemotherapy followed by surgery and/ or radiotherapy (RT). Treatment and survival results are reported and compared to results obtained in tre