Familial Mediterranean Fever (FMF) is a recessive inherited disorder affecting Sephardic Jews, Arabs, Armenians and Turks. The gene responsible for FMF was recently cloned and several disease-associated mutations have been described. We have evaluated seven MEFV mutations in 460 chromosomes of 230 u
✦ LIBER ✦
Reduced MEFV messenger RNA expression in patients with familial Mediterranean fever
✍ Scribed by Cécile Notarnicola; Marie-Noëlle Didelot; Isabelle Koné-Paut; Fabienne Seguret; Jacques Demaille; Isabelle Touitou
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 196 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To define the frequency of the R92Q tumor necrosis factor receptor–associated periodic syndrome (TRAPS) mutation in patients with familial Mediterranean fever (FMF) and to study the role of this mutation in FMF. ## Methods Ninety‐two FMF patients and 250 controls were ge
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