Reduced intracellular content of methotr
โ
Rivka Barg; Sara Shabtai
๐
Article
๐
1991
๐
Springer
๐
English
โ 458 KB
In plant cells methotrexate (MTX) may exert its toxic effect through several mechanisms, including inhibition of its target protein dihydrofolate reductase. Resistance based on a mechanism operating before MTX binds to proteins should confer protection to plant cells. A methotrexate-resistant cell l