Reduced intensity conditioning regimen with fludarabine, busulfan, and low-dose TBI (Flu-BU2-TBI): Clinical efficacy in high-risk patients
✍ Scribed by Mutsumi Takahata; Satoshi Hashino; Kohei Okada; Masahiro Onozawa; Kaoru Kahata; Junichi Sugita; Akio Shigematsu; Takeshi Kondo; Satoshi Yamamoto; Tomoyuki Endo; Mitsufumi Nishio; Yoichi M. Ito; Junji Tanaka; Takao Koike; Masahiro Asaka; Masahiro Imamura
- Book ID
- 101438574
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 159 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Abstract
Reduced intensity conditioning (RIC) regimens are widely used in allogeneic stem cell transplantation (SCT). In this study, we retrospectively investigated the clinical outcomes of RIC with fludarabine (Flu; 180 mg/m^2^), intravenous busulfan (BU; 6.4 mg/kg) or oral BU (8 mg/kg), and low‐dose total body irradiation (TBI; 4 Gy) (Flu‐BU2‐TBI) in 66 patients (median age: 54.5 years) with various hematological malignancies. Thirty‐eight patients (58%) were high‐risk patients (median age: 56 years). The overall survival rate at 2 years of the high‐risk patients was 64.5%, which was comparable to the survival rate of 70.9% in standard‐risk patients (P = 0.68). The relapse rates at 2 years in the standard‐risk and high‐risk patients were 16 and 28%, respectively, and day 100 treatment‐related mortality rates were 0 and 6%, respectively. The Flu‐BU2‐TBI regimen for high‐risk patients showed therapeutic effects equivalent to those for standard‐risk patients and favorable outcomes compared with those of other previous RIC regimens. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.