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Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia

✍ Scribed by Ulf Andersson; Jan-Erik Hägström; Edward D. Levin; Ulf Bondesson; Milan Valverius; Dr. Lars M. Gunne

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
616 KB
Volume
4
Category
Article
ISSN
0885-3185

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✦ Synopsis

Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five T D patients, who all had a sudden death, a signifcant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.

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