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Reduced frequencies of Mitomycin-C induced sister chromatid exchanges in AKR Mice

✍ Scribed by David Kram; Edward L. Schneider

Publisher: Springer
Year: 1978
Tongue: English
Weight: 333 KB
Volume: 41
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00278870

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✦ Synopsis

The frequencies of base-line and Mitomycin-C (MMC) induced sister chromatid exchanges (SCE) were surveyed in four inbred strains of mice. In contrast to the C57Bl/6J, CBA/J, and A/J strains where frequencies of SCE increased linearly with increasing dose of MMC, levels of SCE were significantly lower in AKR/J mice at high MMC concentrations. At a dose of 5 mg/kg MMC, chromosomal aberrations were more frequent in bone marrow cells of AKR/J mice than in C57Bl/6J mice. These observations suggest an altered response to DNA damage in the AKR mouse strain.

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## Abstract Frequencies of sister chromatid exchanges (SCE) were analyzed in bone marrow cells of mice injected with mitomycin C (MMC) both before and during infusion with bromodeoxyuridine (BrdU). Administration of MMC at 1, 6.5, and 13 hours after the onset of BrdU infusion resulted in the induct