The mdr1 gene, first member of the human multidrug-resistance gene family, is a major gene involved in cellular resistance to several drugs used in anticancer chemotherapy. Its product, the drug-excreting P-glycoprotein, shows a bipartite structure formed by two similar adjacent halves. According to
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Reduced formation of lesions in the DNA of a multidrug-resistant L1210 subline selected for teniposide resistance
β Scribed by DeWayne Roberts; P. David Foglesong; Evangelos Parganas; Lee Wiggins
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 867 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0344-5704
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A transformation system using resistance to the antibiotic cycloheximide as a dominant selectable marker was developed for the pathogenic yeast Cryptococcus neoformans. A 3.5 kb DNA fragment containing a gene encoding the ribosomal protein L41 was cloned from a wild-type strain of C. neoformans whic