Gap junctions are an important means for intercellular communication during development, processes of tissue differentiation, and in maintenance of adult tissue homeostasis. We investigated the expression levels and distribution of connexin-43 (Cx-43), the most abundant astrocytic gap junction prote
Reduced expression of the gap junction protein Connexin 43 in keratoconus
β Scribed by Gatzioufas, Z; Charalambous, P; Thanos, S
- Book ID
- 110037049
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 164 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-222X
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## Abstract The present immunocytochemical study examines in the rat ovary the pattern of expression of connexin 43 (Cx43), a subunit of gap junctions. Using a wellβcharacterized specific antiserum against rat Cx43, immunoreactivity was not detected in the fetal ovary, i.e., prior to follicular for
Gap junctional intercellular communication (GJIC) has been proposed as a cellular mechanism for tumour suppression and there is experimental evidence in support of this. If aberrant GJIC contributes to the formation of human breast tumours, one might expect that the connexins (gap junction proteins)