Reduced Expression of nm23 Is Associated with Metastasis of Human Gastric Carcinomas
β Scribed by Nakayama, Hirofumi ;Yasui, Wataru ;Yokozaki, Hiroshi ;Tahara, Eiichi
- Book ID
- 108580755
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1993
- Tongue
- English
- Weight
- 645 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0910-5050
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## BACKGROUND. Expression of nm23 has been shown to be inversely correlated with the metastatic potential of several human cancers. In the current study, the expression and prognostic impact of nm23 was immunohistochemically studied in 413 curatively resected gastric carcinomas. ## METHODS. Tumor
The nm23 gene is a potential metastasis-suppressor gene originally identified in a murine melanoma line. Several investigators have reported the probable inverse association of nm23 expression with disease prognosis and/or metastasis. Since there are now 2 known isotypes of human nm23, namely nm23-H