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Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas

✍ Scribed by Hiromasa Fujii; Kanya Honoki; Toshifumi Tsujiuchi; Akira Kido; Kazuhiro Yoshitani; Toshio Mori; Yoshinori Takakura

Book ID
116295545
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
765 KB
Volume
362
Category
Article
ISSN
0006-291X

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## Abstract Loss of p16^INK4a^ protein expression has frequently been related to DNA methylation in association with gene silencing. Although the methylation status of exon1Ξ± for p16^INK4a^ involvement in various cancers has been extensively analyzed, it has been pointed out that some inconsistenci