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Reduced expression of human mismatch repair genes in adult T-cell leukemia

✍ Scribed by Hiroaki Morimoto; Junichi Tsukada; Yoshihiko Kominato; Yoshiya Tanaka

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
217 KB
Volume
78
Category
Article
ISSN
0361-8609

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## Background: Several convincing studies have shown that the hmsh2 gene plays major roles in mismatch repair by recognizing mismatched bases and preventing mutations during dna replication. loss of this function may result in the accumulation of dna replication errors or even the mutator phenotype