## Abstract Acute liver failure (ALF) is consistently accompanied by alterations in brain energy metabolites and recent nuclear magnetic resonance (NMR) studies suggest disturbances in brain oxidative metabolism in experimental ALF. Glucose transport across the bloodβbrain barrier is essential to s
Reduced Expression of Astrocytic Glycine Transporter (Glyt-1) in Acute Liver Failure
β Scribed by Claudia Zwingmann; Paul Desjardins; Alan Hazell; Nicolas Chatauret; Adriana Michalak; Roger F. Butterworth
- Book ID
- 110413346
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 228 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0885-7490
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π SIMILAR VOLUMES
Two membrane-localized transporter proteins (GLYT1 and GLYT2) are responsible for removal of extracellular glycine in the mammalian CNS. Whereas GLYT1 seems to be expressed mainly in glial cells, GLYT2 is neuronal. The highest concentrations of both transporters are found in glycinergic areas of the
## Abstract Cerebral edema and hepatic encephalopathy are major complications of acute liver failure. Brain herniation caused by increased intracranial pressure as a result of cell swelling is the major cause of death in this condition. Evidence available currently suggests that the rapid accumulat