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Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition

✍ Scribed by Pritam Das; M.Paul. Murphy; Linda H. Younkin; Steven.G. Younkin; Todd E. Golde

Book ID
117412191
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
248 KB
Volume
22
Category
Article
ISSN
0197-4580

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## Abstract The main objective of the present study was to develop an alternative singly‐transgenic (tg) hAPP model where amyloid deposition will occur at an earlier age. For this purpose, we generated lines of tg mice expressing hAPP751 cDNA containing the London (V717I) and Swedish (K670M/N671L)