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Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome

✍ Scribed by Bengt E Hildebrand; George G Nomikos; Peter Hertel; Björn Schilström; Torgny H Svensson


Book ID
114003301
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
237 KB
Volume
779
Category
Article
ISSN
0006-8993

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In the present study the neuronal expression of Fos, the protein product of c-fos, was used to study changes in neuronal activity in nerve terminal regions of the ascending dopaminergic system during nicotine withdrawal. Rats were infused for 14 days with nicotine (9 mg/kg/day nicotine hydrogen tart