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Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors

✍ Scribed by Shulamith H. Shafer; Scott H. Phelps; Carol L. Williams

Book ID: 113994233
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 492 KB
Volume: 56
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(98)00260-3

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## Abstract ## BACKGROUND Topotecan (9‐dimethylaminomethyl‐10‐hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of t