Reduced DNA Repair Capacity in Breast Cancer Patients and Unaffected Individuals from Breast Cancer Families
β Scribed by N.Meenakshi Rao; Sanjay A Pai; S.R Shinde; S.N Ghosh
- Book ID
- 114136357
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 226 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0165-4608
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π SIMILAR VOLUMES
## Abstract The capacity of peripheral blood lymphocytes to repair Xβrayβinduced DNA damage, manifest as chromatid damage 30β90 min after G~2~βphase Xβirradiation, was measured among available members of a family exhibiting a cluster of breastβcancer cases occurring in one generation. The cancer pa
Defective DNA repair capacity as measured by enumerating chromatid aberrations induced in G 2 phase by X-irradiation may explain increased risk of breast cancer among relatives of patients. In the present study, chromatid damage was determined in peripheral blood lymphocytes (PBL) following in vitro