✦ LIBER ✦

Reduced coxsackie antibody titres in Type 1 (insulin-dependent) diabetic patients presenting during an outbreak of coxsackie B 3 and B 4 infection

✍ Scribed by J. P. Palmer; M. K. Cooney; R. H. Ward; J. A. Hansen; J. B. Brodsky; C. G. Ray; J. R. Crossley; C. M. Asplin; R. H. Williams

Publisher: Springer
Year: 1982
Tongue: English
Weight: 359 KB
Volume: 22
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00282584

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✦ Synopsis

The potential role of antecedent viral infection in the pathogenesis of Type 1 (insulin-dependent) diabetes was investigated by measuring antibody titres to several viruses in serum obtained at the time of diagnosis of diabetes. An outbreak of Coxsackie B4 infection followed by a wave of Coxsackie B3 and B5 infections occurred in Seattle during the time viral serology was obtained in the diabetic patients. Antibody titres to Cocksackie B5 and Influenza A and B viruses were comparable in diabetics and matched control subjects, but antibody titres to Cocksackie B3 and B4 were lower in the diabetics and a low antibody titre to Coxsackie B3/B4 was associated with a significantly increased relative risk of diabetes.

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