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Reduced COX-2 protein expression in human colorectal cancer exhibiting defective mismatch repair

✍ Scribed by William, E.; Karnes, ; Raymond, N.; DuBois, ; Rebecca, Shattuck-Brandt; Burgart, Lawrence J.; Tester, David J.; Thibodeau, Stephen N.

Book ID
121972534
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
170 KB
Volume
114
Category
Article
ISSN
0016-5085

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Most colorectal adenomas and carcinomas arise in the setting of chromosomal instability and progressive loss of heterozygosity. Approximately 15-20% of colorectal neoplasms arise through a distinct genetic pathway characterized by microsatellite instability (MSI) and frequent loss of expression of o