Reduced bone mineral density and unbalanced bone metabolism in patients with inflammatory bowel disease

✍ Scribed by Dr. med. Claudia Schulte; Axel U. Dignass; Klaus Mann; Harald Goebell

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 795 KB
• Volume: 4
• Category: Article
• ISSN: 1078-0998
• DOI: 10.1002/ibd.3780040403

✦ Synopsis

Drvi \ions of Endocrinology mid *Gastroenterologi. Department of Inteinal Medicine. Utui ersitl 01 Ec yen, German\ Summary: Patients with chronic inflammatory bowel diseases (IBD) are at increased risk to develop osteopenia and osteoporosis. New parameters for the assessment of bone formation and especially bone resorption have significantly improved the diagnostic procedures to characterize bone metabolism. Biochemical characterization of bone turnover in TBD patients may provide important information about the pathogenesis of osteoporosis in this patient population. A cross-sectional study was performed. One hundred forty-nine patients (77 men, 52 premenopausal, and 20 postmenopausal women) with TBD (1 04 with Crohn's discase [CD] and 45 with ulcerative colitis [UC]) underwent clinical, osteodensitometric, and metabolic bone assessment. Bone mineral density was determined by dual energy X-ray absorptiometry. Bone fonnation (bone alkaline phosphatase), bone resorption (N-terminal telopeptide of type-I collagen, free desoxypyridinoline. total pyridinoline, and desoxy-pyridinoline). vitamin D, and parathyroid hormone were assessed. Thirty-six percent of patients with CD and 32% with UC showed osteopenia, 15% with CD and 7% with UC showed osteoporosis. Bone resorption was significantly increased in IBD patients compared to normal controls, whereas bone lormation did not show a compensatory increase. Bone formation wah even more suppressed in the subset of patients currently treated with corticosteroids. Our data confirm the high prevalence of osteopenia and osteoporosis reported in IBD patients. Furthermore, we provide evidence for an increascd bone rcsorption accompanied by low bone formation in IBD patients.