Reduced bone marrow uptake of indium-111 labelled monoclonal antibody after radiotherapy

✍ Scribed by Harumi Sakahara; Hisashi Onodera; Hisataka Kobayashi; Zhengsheng Yao; Ikuo Yamashina; Junji Konishi

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 390 KB
• Volume: 21
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00182363

✦ Synopsis

Uptake of indium-111 in bone marrow is seen in patients who have received ~llIn-labelled antibody. We report a case in which 111In uptake was not seen in the area of previous irradiation whereas fairly high uptake was noted in other bone marrow areas, l~llnlabelled monoclonal antibody, which reacts with mucin, was injected into a patient with cancer of the sigmoid colon who had received radiotherapy for uterine cervical cancer 5 years previously. M a r k e d accumulation of the antibody was observed in the tumour. Uptake of lllIn in bone marrow was also seen except in the previously irradiated pelvic region. This p h e n o m e n o n supports the idea that bone marrow uptake of lI~In is the result of transchelation of 11JIn from antibody to transferrin.