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Reduced biosynthesis and secretion of type II collagen in transgenic mice with a Gly574Ser mutation in Col2α1 results in abnormal skeletal development

✍ Scribed by B.K. Maddox; S. Garofalo; C. Smith; D.R. Keene; W.A. Horton


Book ID
117640593
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
106 KB
Volume
16
Category
Article
ISSN
0945-053X

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Skeletal development in transgenic mice
✍ B. Kerry Maddox; Silvio Garofalo; Chad Smith; Douglas R. Keene; William A. Horto 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

Skeletal development of transgenic mice with a type II collagen mutation was analyzed and compared with wild-type littermates. The single base substitution in Col2a1 resulted in a glycine to serine mutation within the helical domain and corresponded to one previously identified in a patient with the