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Reduced Antidiabetic Effect of Metformin and Down-regulation of Hepatic Oct1 in Rats with Ethynylestradiol-Induced Cholestasis

โœ Scribed by Hyo-Eon Jin; Soon-Sun Hong; Min-Koo Choi; Han-Joo Maeng; Dae-Duk Kim; Suk-Jae Chung; Chang-Koo Shim


Publisher
Springer US
Year
2008
Tongue
English
Weight
253 KB
Volume
26
Category
Article
ISSN
0724-8741

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## Abstract Brain edema in acute hepatic encephalopathy (HE) is due mainly to swelling of astrocytes. Efflux of potassium is implicated in the prevention of glial swelling under hypoosmotic conditions. We investigated whether pathogenic factors of HE, glutamine (Gln) and/or ammonia, induce alterati